Novel Drug Delivery Systems

Unit 1

Controlled drug delivery systems:

Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations

Polymers:

Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery

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Unit 2

Microencapsulation:

Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery system:

Introduction, Principles of bioadhesion /mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems:

Introduction, advantages and disadvantages, concept of implantsand osmotic pump

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Unit 3

Transdermal Drug Delivery Systems:

Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems:

Introduction, advantages, disadvantages, approaches for GRDDS - Floating, high density systems, inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system:

Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

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Unit 4

Targeted drug Delivery:

Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

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Unit 5

Ocular Drug Delivery Systems:

Introduction, intra ocular barriers and methods to overcome - Preliminary study, ocular formulations and ocuserts

Intrauterine Drug Delivery Systems:

Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications