Pharmacology 2

Unit 1

1. Pharmacology of drugs acting on cardio vascular system

• Introduction to hemodynamic and electrophysiology

• Drugs used in congestive heart failure

• Anti-hypertensive drugs.

• Anti-anginal drugs.

• Anti-arrhythmic drugs.

• Anti-hyperlipidemic

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Unit 2

1. Pharmacology of drugs acting on cardio vascular system

• Drug used in the therapy of shock.

• Hematinics, coagulants and anticoagulants.

• Fibrinolytics and anti-platelet drugs

• Plasma volume expanders

2. Pharmacology of drugs acting on urinary system

• Diuretics

• Anti-diuretics.

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Unit 3

3. Autocoids and related drugs

• Introduction to autacoids and classification

• Histamine, 5-HT and their antagonists.

• Prostaglandins, Thromboxanes and Leukotrienes.

• Angiotensin, Bradykinin and Substance P. e. Non-steroidal anti-inflammatory agents

• Anti-gout drugs

• Antirheumatic drugs

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Unit 4

5. Pharmacology of drugs acting on endocrine system

• Basic concepts in endocrine pharmacology. b. Anterior Pituitary hormones- analogues and their inhibitors.

• Thyroid hormones- analogues and their inhibitors.

• Hormones regulating plasma calcium level- Parathormone, Calcitonin and Vitamin-D.

• Insulin, Oral Hypoglycemic agents and glucagon.

• ACTH and corticosteroids.

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Unit 5

5. Pharmacology of drugs acting on endocrine system

• Androgens and Anabolic steroids.

• Estrogens, progesterone and oral contraceptives.

• Drugs acting on the uterus.

6. Bioassay

• Principles and applications of bioassay.

• Types of bioassay

• Bioassay of insulin, oxytocin, vasopressin, ACTH,d-tubocurarine,digitalis, histamine and 5-HT